Analysis of Polymer Plastication in a Twin Screw Extruder

Continuous Granulation with a Twin-Screw Extruder

Wet granulation in a twin-screw extruder: implications of screw design.

Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study endeavored to systematically examine t...

Simulation of Polymeric Flow in a Twin-screw Extruder: an Analysis of Elongational Viscosity Effects

Flow of a polymer in an intermeshing co-rotating twin-screw extruder is simulated. Effect of elongational viscosity on the flow is analyzed using independent powerlaw models for the shear and elongational viscosities. Axial component of the velocity is found to be maximum in the intermeshing region of the extruder. Axial component of velocity, which determines the throughput of the extruder, de...

Modeling, sensitivity analysis and parameter identification of a twin screw extruder

Following the recent success of hot-melt extrusion in the pharmaceutical field, monitoring and control are increasingly applied. In this study, a mathematical model consisting of mass and energy balance partial differential equations is developed and parameters related to material transportation are inferred from experimental data collected from a pilot plant. This data is relative to the outpu...

Modeling of Transport Phenomena and Melting Kinetics of Starch in a Co-Rotating Twin-Screw Extruder

A mathematical model was developed to simulate fluid flow, heat transfer, and melting kinetics of starch in a co-rotating intermeshing twin-screw extruder (TSE). The partial differential equations governing the transport phenomena of the biomaterial in the extruder were solved by a finite element scheme. For validating the model, the predicted product pressure, bulk temperature at the entrance ...